The pair topped fashion bible Vanity Fair's annual poll for the second year in a row, and beat off stiff competition from David and Victoria Beckham and Ashton Kutcher and Demi Moore.
Using the tagline "It's all in the family", the magazine praised Angelina for the way she dressed while pregnant and noted Brad's numerous flawless red-carpet appearances.
Michelle Obama, the wife of the American Democratic presidential candidate Barack Obama, came top of the women's poll, with the magazine jokingly referring to her as "our commander-in-sheath". Michelle became a fashion icon in June when there was a run on a $148 Donna Ricci dress after she was seen wearing it.
Former model and French First Lady Carla Bruni-Sarkozy, Kate Middleton - the girlfriend of Britain's Prince William - Sarah Jessica Parker, Oscar-winner Tilda Swinton and Evelyn Lauder were also featured.
Soccer star David did make the men's list along with, 'James Bond' actor Daniel Craig, rapper Kanye West and fashion designer Karl Lagerfeld.
Meanwhile, People magazine has secured the rights to publish the first pictures of Angelina and Brad's newborn twins, Knox Leon and Vivienne Marcheline.
The publication is rumoured to have paid between $10 and $15 million for the photographs. The couple are planning to donate the money to charity.
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