The humanitarian talk show host topped a list compiled by Parade magazine, after donating a staggering $50.2 million to various charities in the last year.
As well as her huge donations, Oprah is the founder of Oprah's Angel Network which helps the underprivileged women and children worldwide.Other stars to feature in the list include Mel Gibson, Barbra Streisand and Brad Pitt and Angelina Jolie.
he Hollywood couple were ranked at number six, after giving away $8.4million through the Jolie-Pitt Foundation, which contributes funds to help reconstruct hurricane ravaged New Orleans, provides refugee aid and cross cultural understanding.
The stars who welcomed twins Knox and Vivienne into the world in July this year - even spend Christmas Day helping people in need.Angelina previously revealed: "It's important to teach our children that it's not about what they're going to get, but it's about who they're going to think of."
The list was compiled by The Giving Back Fund from public records of donations during 2007.
Parade magazine's Most Generous Stars, full list:
1. Oprah Winfrey
2. Herb Alpert
3. Barbra Streisand
4. Paul Newman
5. Mel Gibson
6. Angelina Jolie and Brad Pitt
7. (tie) Lance Armstrong
7. (tie) Michael Jordan
7. (tie) Eric Lindros
10. Rush Limbaugh
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