Johnny is nominated for the Best Comedic Performance award for his role as Jack Sparrow in 'Pirates of the Caribbean: At World's End', and for the Best Villain award for his lead role in 'Sweeney Todd: The Demon Barber of Fleet Street'.
Other big names set to present awards at the June 1 bash include Will Smith, Charlize Theron, Sarah Jessica Parker, Ben Stiller, Robert Downey Jr., Jack Black, Lindsay Lohan, Mark Wahlberg, Steve Carell and Anne Hathaway.
'Austin Powers' star Mike Myers will host the awards, while Coldplay and the Pussycat Dolls are set to perform.
Nominees were announced earlier this month, with 'Superbad' leading the board with five nominations.
'Juno' is up for four awards, while 'Enchanted', 'Pirates of the Caribbean: At World's End', 'Knocked Up' and 'Transformers' each have three nominations.
The awards take a lighter look at films, with categories including Best Fight, Best Kiss and Best Villain.
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